Figure 2
From: Multiscale modeling for clinical translation in neuropsychiatric disease
Neuroprosthetic stimulation fails to stop seizure in a neocortical model. Four brain areas are shown at the upper right (color coded) with corresponding coloring for local field potentials (LFPs) at the top of each panel. Rasters have a different cell-coded coloring; each trace is 500 ms duration. (A) Seizure with activity across all areas nearly simultaneous at 12 Hz. (B) Attempted seizure abort with one area of stimulation fails, instead creating a faster seizure (16 Hz). (C) Seizure aborted with activation of inhibitory cells alone. From Lytton et al. [24].